Nystatin (Fungicidin)(Synonyms: 制霉菌素)
Nystatin (Fungicidin) 是一种口服活性多烯抗真菌抗生素,对酵母菌和支原体有效。
产品描述
Nystatin (Fungicidin) is a polyene antifungal antibiotic [1].
Antifungal antibiotic is a pharmaceutical fungicide used to treat and prevent mycoses.
Nystatin is a polyene antifungal antibiotic that is effective against yeast and mycoplasma [1]. In liquid media, Nystatin inhibited C. albicans at concentrations of 5-20 U/ml[2].
In a 200 clinical isolates, which comprised of 113 Candida albicans, 54 Candida glabrata, 11 Candida parapsilosis, 11 Candida tropicalis and 11 Candida krusei. Nystatin exhibited MIC90 value of 4 mg/L against C. albicans isolates and all non-albicans Candida species tested. The results confirmed C. Albicans was most frequently susceptible and Nystatin could be used to treat vulvovaginal candidiasis caused by non-albicans Candida species. Nystatin would be an important choice for women affected by non-albicans Candida species which present higher resistance to the imidazole-based treatments [3].
制霉菌素(Fungicidin)是一种多烯类抗真菌抗生素[1]。
抗真菌抗生素是一种用于治疗和预防真菌病的药物真菌剂。
制霉菌素是一种多烯类抗真菌抗生素,对酵母菌和支原体有有效的抗菌作用[1]。在液体培养基中,制霉菌素以5-20 U/ml的浓度抑制了白色念珠菌(Candida albicans)[2]。
在200个临床分离株中,包括113个白色念珠菌、54个光滑念珠菌、11个副银白念珠菌、11个热带银白念珠菌和11个克鲁氏念珠菌。制霉菌素对C. albicans分离株和所有检测的非白色念珠菌菌株的MIC90值均为4 mg/L。结果证实C. albicans最常易感,制霉菌素可用于治疗由非白色念珠菌菌株引起的阴道念珠菌病。对于对咪唑类药物治疗具有较高抗药性的女性患者,制霉菌素是一种重要选择[3]。
References:
[1]. Childs AJ. Effect of Nystatin on Growth of Candida albicans During Antibiotic Therapy. Br Med J, 1956, 1(4968): 660-662.
[2]. Stewart GT. Laboratory and Clinical Studies with Nystatin in Post-antibiotic Mycotic Infections. Br Med J, 1956, 1(4968): 658-660.
[3]. Choukri F, Benderdouche M, Sednaoui P. In vitro susceptibility profile of 200 recent clinical isolates of Candida spp. to topical antifungal treatments of vulvovaginal candidiasis, the imidazoles and nystatin agents. J Mycol Med, 2014, 24(4): 303-307.
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