TBTU 试剂 GLPBIO

TBTU(Synonyms: 2-(1H-苯并三偶氮L-1-基)-1,1,3,3-四甲基脲四氟硼酸酯) 

肽偶联剂

产品描述

IC50: Not available.

The utilization of new peptide coupling reagents in organic synthesis has greatly flourished the development of peptide synthesis. TBTU, 2-(1H-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronoium hexafluorphosphate, serves as a typical peptide coupling reagent which has a relatively lower racemization. In normal condition, coupling reactions mediated by TETU take only six minutes to complete when HOBt is added. Moreover, racemization in this reaction could be reduced to insignificant levels. Due to these features, TBTU is regarded as one of the key reagents of choice in both manufactory and lab. [1]

In vitro: It was reported that during synthesis of the macrocyclic peptide cyclotheonamide B, TBTU played an important role in coupling steps. Studies showed that TBTU had been successfully used in several coupling reactions, for instance, this reagent was suitable for couplings involving proline nitrogen, and therefore served as a crucial reagent for the macrolactamization. Although TBTU normally proceeded with little racemization, to suppress the racemization completely, HOBt was also required. Thus, in a typical reaction system, TBTU was added into 0.5 mM solution of CH2Cl2, followed by addition of HOBt and pyridine. Finally, cyclopentapeptide was obtained with a yield of 61%. [1]

In vivo: So far, no in vivo data has been reported.

Clinical trial: So far, no clinical trial has been conducted.

Reference:
[1]Bastiaans HM, van der Baan JL and Ottenheijm HC.  Flexible and convergent total synthesis of cyclotheonamide B. J. Org. Chem. 1997; 62: 3880-9.

Chemical Properties

溶解性数据

制备储备液
		1 mg	5 mg	10 mg
	1 mM	3.1143 mL	15.5715 mL	31.1429 mL
	5 mM	0.6229 mL	3.1143 mL	6.2286 mL
	10 mM	0.3114 mL	1.5571 mL	3.1143 mL